A study testing whether a new weekly shot from Massachusetts General Hospital, tirzepatide, can help with weight.
- Who can join
- Adults 18+, have obesity, BMI 27+.
- What you take
- tirzepatide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 3.3 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Primary condition: Obesity.
Full scientific study title: Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity.
Who can join
Adults 18+, have obesity, BMI 27+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- BMI >=30 kg/m2 or >=27kg/m2 with at least one weight-related medical condition
- Have a history of at least one self-reported unsuccessful behavioral effort to lose body weight
- Have an established primary care provider
Key exclusion criteria
- Current or prior history of diabetes mellitus based on self-report, use of diabetes medications, HbA1c >=6.5%, or fasting glucose >=126 mg/dL
- Any single serum transaminase level (i.e., ALT, AST, alk phos) >=3x the upper limit of normal (ULN)
- Serum lipase and/or amylase levels >=2x ULN
- Serum bilirubin level >1.6 mg/dL
- Chronic kidney disease (e.g., estimated glomerular filtration rate (eGFR) < 45 mL/min)
Where this study is enrolling
This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.
Massachusetts1 site
- Massachusetts General HospitalBoston, Massachusetts
Timeline
Started enrolling: 2025-11-05. Expected completion: 2029-03-31. Last updated on ClinicalTrials.gov: 2026-03-27.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
Other GLP-1 clinical trials
Back to the full directory → or take the matching quiz if you want clinical trials filtered to your conditions and location.
