A study of a GLP-1 medicine, semaglutide, in people with abdominal wall hernia.
Recruiting now. Registry record last updated March 23, 2026.
- Who can join
- Adults 18+, have abdominal wall hernia, BMI 40+.
- What you take
- Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
- How long it lasts
- The full study runs about 4 years.
- What you get
- Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.
What this study is for
Primary condition: Abdominal Wall Hernia.
Full scientific study title: Preoperative Weight Loss for Open Abdominal Wall Reconstruction.
Who can join
Adults 18+, have abdominal wall hernia, BMI 40+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.
Full medical eligibility (for you and your doctor)verbatim from the registry
This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.
Key inclusion criteria
- Adults having open retromuscular ventral hernia repair with an anticipated posterior component separation with transversus abdominis release and synthetic mesh
- BMI 40-55 kg/m2 and who are not planning to pursue weight loss surgery for any of the following reasons: they are not a candidate for weight loss surgery, cannot pursue weight loss surgery for insurance reasons, or are not interested in pursuing weight loss surgery.
Key exclusion criteria
- Lack of English language fluency
- Urgent need for repair as determined by surgeon judgement
- Pregnant patients
- Permanent stoma in place
- Isolated flank hernia
Where this trial is enrolling
This trial has 2 sites across 2 states. Contact a site coordinator directly to start screening.
Illinois1 site
- Northwestern UniversityChicago, Illinois
Ohio1 site
- Cleveland Clinic Main CampusCleveland, Ohio
Timeline
Started enrolling: June 19, 2023. Expected completion: June 1, 2027. Last updated on ClinicalTrials.gov: March 23, 2026.
Official source
Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:
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