Enrolling now · NCT05819138
A study testing whether a GLP-1 medicine from University of Colorado, Denver, semaglutide, can lower blood sugar and help with weight.
- Who can join
- Adults 18 to 49, have type 1 diabetes, BMI 20+.
- What you take
- semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
- How long it lasts
- The full study runs about 4.5 years; your own time in it is usually shorter.
- What you get
- The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.
What this study is for
Full study title: Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes.
Primary condition: Diabetes Mellitus, Type 1.
Who can join, in detail
Age 18 to 49
Sex All
BMI 20 to 45
Key inclusion criteria
- Age 18-49 years
- 1) T1D diagnosis defined as positive T1D-associated antibody(ies) or 2) a clinical diagnosis of T1D plus insulin requirement since diagnosis
- Insulin pump or automated insulin delivery systems
- Estimated glomerular filtration rate (eGFR) >= 45 ml/min/1.73m2
- Stable doses of drugs altering cardiovascular and renal function (e.g., Angiotensin-Converting Enzyme Inhibitor (ACEi), Angiotensin Receptor Blocker (ARB), statins, diuretics)
Key exclusion criteria
- HbA1c >9%, recent diabetic ketoacidosis (DKA) or hospitalization
- Major congenital heart disease, anemia, severe non-proliferative retinopathy, proliferative retinopathy
- History/family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2 (MEN2), pancreatitis
- Current/planned pregnancy or nursing
- Uncontrolled thyroid disease or hypertension (HTN) (>= 160/100 mm Hg despite optimal therapy)
Where this study is enrolling
This trial has 2 US sites across 2 states. Contact the site coordinator directly to start the screening process.
Colorado
- University of Colorado Anschutz Medical CampusAurora, Colorado
Washington
- University of Washington Medicine Diabetes Institute (UWMDI)Seattle, Washington
Timeline
Started enrolling: 2023-06-21. Expected completion: 2027-12-01. Last updated on ClinicalTrials.gov: 2026-03-04.
Official source
We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:
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