A study testing whether a GLP-1 medicine from University of Virginia, semaglutide, works for this condition.

Who can join: Adults 18 to 75, have nafld, BMI 27+.
What you take: semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The full study runs about 2.5 years; your own time in it is usually shorter.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 2Sponsor University of VirginiaDrug semaglutideClass GLP-1 RASites 1 USEnrollment target 50

What this study is for

Primary condition: NAFLD.

Full scientific study title: Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant.

Who can join

Age18 to 75SexAnyBMI27 or higher

Adults 18 to 75, have nafld, BMI 27+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Male or female age 18-75 years who received LT for any indication (i.e. NASH, hepatitis C, alcohol-induced cirrhosis, autoimmune hepatitis, etc.)
Liver transplant surgery within 8-24 weeks prior to randomization
Fasting glucose > 125 mg/dL or presence of diabetes (HbA1c>=6.5% or use of diabetes medications) or pre-diabetes (HbA1c >5.7%)
Ability to provide informed consent
Discharged from the hospital following LT surgery

Key exclusion criteria

BMI<= 27kg/m2
GFR (Glomerular Filtration Rate) <= 25 ml/min/1.73m2
Type 1 autoimmune diabetes (by anti-GAD (glutamic acid decarboxylase) or history of ketoacidosis)
History of gastroparesis
Familial or personal history of medullary thyroid cancer or MEN (Multiple Endocrine Neoplasia) 2

Where this study is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Virginia1 site

Virginia Commonwealth University
Richmond, Virginia

Follow this trial

We email you if NCT05424003 changes status, adds new sites in your state, or if a similar trial opens for the same condition. No spam, opt out any time.

Timeline

Started enrolling: 2024-02-22. Expected completion: 2026-08-01. Last updated on ClinicalTrials.gov: 2026-06-04.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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