A study testing whether a GLP-1 medicine from Brigham and Women's Hospital, semaglutide, can lower blood sugar and help with weight.

Who can join

Adults 40 to 80, have type 2 diabetes.

What you take

semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.

How long it lasts

The full study runs about 6.5 years; your own time in it is usually shorter.

What you get

The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

What this study is for

Full study title: PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes.

Primary condition: Type2Diabetes. Also studied in: ASCVD.

Who can join, in detail

Key inclusion criteria

• Type 2 diabetes based on clinical diagnosis
• HbA1c >=6% measured within 12 months prior to screening
• Secondary prevention cohort (at least 70% of cohort):
• Age 40 to 80 years
• Evidence of established atherosclerotic cardiovascular disease (ASCVD), as defined by one or more of the following

Key exclusion criteria

• Known or suspected diabetes of other cause (type 1 diabetes, pancreatogenic diabetes, monogenic diabetes, etc.)
• Any background diabetes medication regimen will be allowed in this pragmatic trial with the following proviso:
• History of diabetic ketoacidosis
• Active diabetic foot ulcer
• History of pancreatitis

Where this study is enrolling

This trial has 36 US sites across 25 states. Contact the site coordinator directly to start the screening process.

Timeline

Started enrolling: 2022-09-26. Expected completion: 2029-03-01. Last updated on ClinicalTrials.gov: 2026-04-13.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and editorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas. About this site · LinkedIn · Contact