A study testing whether a GLP-1 medicine from Srinvasan Beddhu, semaglutide, can protect the kidneys.

Who can join: Adults 20+, have chronic kidney disease.
What you take: semaglutide, given as part of the study at no cost to you. Some participants may receive a placebo (an inactive version) instead, decided at random.
How long it lasts: The full study runs about 5.3 years; your own time in it is usually shorter.
What you get: The study medication and study-related care at no cost. Compensation varies by study site; many cover travel and provide the study medication at no cost. The trial coordinator will explain what that site offers before you join.

Phase Phase 2Sponsor Srinvasan BeddhuDrug semaglutideClass GLP-1 RASites 2 USEnrollment target 156

What this study is for

Primary condition: Chronic Kidney Diseases. Also studied in: Obesity.

Full scientific study title: Sit Less, Interact and Move More (SLIMM) 2 Study.

Who can join

Age20 and upSexAny

Adults 20+, have chronic kidney disease. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Glomerular Filtration Rate (eGFR) 20 to <60 mL/min/1.73m^2
Able to perform resistance training
Access to compatible "smartphone" or device (i.e., Android, Kindle or Apple with internet connectivity or mobile network), desktop or laptop

Key exclusion criteria

Type 1 Diabetes
History of gastroparesis or paralytic ileus
At baseline, if sedentary time is 25 min/hr or less, measured by accelerometer
Potential contraindications to semaglutide such as a history of pancreatitis, and a family or personal history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma.
Previous bariatric surgery

Where this study is enrolling

This trial has 2 sites across 2 states. Contact a site coordinator directly to start screening.

Find a site near you

California1 site

Stanford University
Stanford, California
Edison Lee650-497-7526elee125@stanford.edu

Utah1 site

University of Utah
Salt Lake City, Utah
Judy Carle801-585-1113jcarle@hsc.utah.edu

Follow this trial

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Timeline

Started enrolling: 2021-12-01. Expected completion: 2027-03-31. Last updated on ClinicalTrials.gov: 2025-06-05.

Official source

We sync this data quarterly from ClinicalTrials.gov, the federal registry for clinical research. Before contacting a site, verify the trial is still recruiting on the official page:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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