A study testing whether a GLP-1 medicine, semaglutide, can help people with prediabetes lower blood sugar.

Recruiting now. Registry record last updated March 13, 2025.

Who can join: Adults 18 to 45, women only, have prediabetes, BMI 25+.
What you take: Semaglutide, given as part of the study. Check ClinicalTrials.gov for this trial's study groups, including any placebo or comparison medicine.
How long it lasts: The full study runs about 4 years.
What you get: Costs vary by study. Ask the study team what this one covers, including the study medicine, visits and travel, before you sign the consent form.

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Phase Phase 4Sponsor Woman'sDrug semaglutideClass GLP-1 RASites 1 USEnrollment target 102

What this study is for

Primary condition: Pre Diabetes. Also studied in: Postpartum Disorder.

Full scientific study title: Treatment to Regress to Normoglycemia in Women with a Recent History of GDM.

Who can join

Age18 to 45SexFemaleBMI25 or higher

Adults 18 to 45, women only, have prediabetes, BMI 25+. A site coordinator confirms whether you qualify during a free screening visit. The exact medical requirements are below.

Full medical eligibility (for you and your doctor)verbatim from the registry

This is the exact wording from ClinicalTrials.gov, including clinical measures (lab values, imaging scores). Bring it to your doctor if any of it is unclear.

Key inclusion criteria

Female
18 - 45 years old (inclusive)
History of gestational diabetes in most recent pregnancy
6 months - 10 years postpartum
BMI ≥ 25 kg/m2

Key exclusion criteria

Body weight \> 350 lb
Pregnant or the intention of becoming pregnant or not using adequate contraceptive measures.
Breastfeeding within 3 months of screening visit 1
Post-menopausal
Desiring pregnancy within study participation period or two months after participation ends (i.e. 10 months from enrolment)

Where this trial is enrolling

This trial has 1 sites across 1 state. Contact a site coordinator directly to start screening.

Louisiana1 site

Woman's Hospital
Baton Rouge, Louisiana
Elizabeth Sutton, PhD225-924-8446elizabeth.sutton@womans.org

Follow this trial

We email you if NCT04873050 changes status, adds new sites in your state, or if a similar trial opens for the same condition.

Timeline

Started enrolling: January 13, 2022. Expected completion: March 1, 2026. Last updated on ClinicalTrials.gov: March 13, 2025.

Official source

Every Monday we check this trial against ClinicalTrials.gov, the federal registry for clinical research. Last checked September 4, 2026. Confirm the current status there before you contact a site:

View on ClinicalTrials.gov →

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John Samaras, Founder and EditorI started GLP Chart after overpaying for a GLP-1 myself. Based in Austin, Texas.
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