Who it's for
Same prescribing audience as Wegovy in practice (BMI ≥30, or BMI ≥27 with comorbidity), though the prescription is for a compounded product rather than the FDA-approved branded version.
What the trials show
Compounded semaglutide's registration trial was STEP-1 (parent molecule, Wegovy) (NEJM, 2021). At 68 weeks at the maximum dose, mean weight loss was 14.9% (12.4 percentage points greater than placebo). 86.4% of patients lost at least 5% of body weight; 50.5% lost at least 15%. Real-world results vary; trial patients are typically more adherent and more closely managed than typical telehealth patients.
Dose schedule
Dose levels: 0.25mg, 0.5mg, 1.0mg, 1.7mg, 2.4mg. Standard practice is to titrate up monthly, holding at any tolerated dose. Maximum dose is Typically titrated to 2.0-2.4mg weekly to mirror Wegovy; many patients reach goal weight at sub-maximum doses and stay there.
What it costs in 2026
| Retail cash (no insurance, no DTC) | Not sold at retail; cash-pay through telehealth programs only |
| Manufacturer DTC (cash-pay direct) | $99-$249/mo via telehealth programs (Mochi $99, Found $159, Noom microdose $99) |
| With insurance + prior authorization | Not covered by insurance. Compounded medications are not eligible for insurance reimbursement as drug products. |
| Compounded version (503A pharmacy) | Cash-pay only by definition. Pricing varies $99-$249/mo depending on program. |
Telehealth programs add a membership fee on top of the medication cost (typically $40-$200/mo). For all-in monthly costs by program, see the chart.
Common side effects
The most commonly reported side effects in the registration trial:
- Same profile as branded semaglutide; nausea, diarrhea, constipation, vomiting most common
- Real-world reports of injection-site reactions occasionally vary by 503A pharmacy
- Rare reports of dosing inconsistency between batches and pharmacies
Boxed warning: Same class warning as branded semaglutide. Compounded preparations are not subject to FDA's full new-drug-approval safety review; sterility and potency rely on the 503A pharmacy's state-board oversight and program-level quality controls.
How Compounded semaglutide differs from related drugs
Same molecule as Wegovy at typical compounded doses. Cheaper. Not FDA-approved as a drug product (the molecule is FDA-approved only as the branded versions). Insurance does not cover. Regulatory exposure has increased through 2025-2026 but compounded semaglutide supply has held up better than compounded tirzepatide.
Programs that prescribe Compounded semaglutide
These programs in our chart prescribe Compounded semaglutide (with insurance coverage where applicable, or as a cash-pay option). Ranked by overall score.
Compounded semaglutide vs other GLP-1s
Editorial disclosure
GLP Chart is an editorial comparison site. We do not dispense, prescribe, or fulfill medications. Talk to a licensed clinician about whether Compounded semaglutide is appropriate for you. Pricing reflects publicly verified rates as of 12 May 2026; verify with the manufacturer or your prescriber before committing.